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, P Kumar Conceptualization, Visualization, Writing - original draft Center for One Health, Global Center for Evidence Synthesis , Chandigarh, India Search for other works by this author on: Oxford Academic J Jayan Data curation, Visualization Center for One Health, Global Center for Evidence Synthesis , Chandigarh, India Search for other works by this author on: Oxford Academic R K Sharma Supervision, Writing - review & editing Graphic Era (Deemed to be University) , Clement Town, India Graphic Era Hill University , Clement Town, India Search for other works by this author on: Oxford Academic A M Gaidhane Validation, Writing - review & editing Jawaharlal Nehru Medical College, and Global Health Academy, School of Epidemiology and Public Health, Datta Meghe Institute of Higher Education , Wardha, India Search for other works by this author on: Oxford Academic Q S Zahiruddin South Asia Infant Feeding Research Network (SAIFRN), Division of Evidence Synthesis, Global Consortium of Public Health and Research, Datta Meghe Institute of Higher Education , Wardha, India Search for other works by this author on: Oxford Academic S Rustagi Supervision, Writing - review & editing School of Applied and Life Sciences, Uttaranchal University , Dehradun, India Search for other works by this author on: Oxford Academic P Satapathy Supervision, Visualization, Writing - review & editing Center for Global Health Research, Saveetha Medical College, and Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha University , Chennai, India Medical Laboratories Techniques Department, AL-Mustaqbal University , Hillah, Iraq Address correspondence to P. Satapathy, Center for Global Health Research, Saveetha Medical College, and Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Saveetha Nagar, Thandalam, Chennai - 602 105, Tamil Nadu, India. email: prakasini.satapathy@gmail.com Search for other works by this author on: Oxford Academic
https://orcid.org/0000-0001-5059-9275 QJM: An International Journal of Medicine, Volume 117, Issue 7, July 2024, Pages 485–487, https://doi.org/10.1093/qjmed/hcae102
Published:
12 June 2024
Article history
Received:
10 May 2024
Published:
12 June 2024
Corrected and typeset:
24 June 2024
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P Kumar, J Jayan, R K Sharma, A M Gaidhane, Q S Zahiruddin, S Rustagi, P Satapathy, The emerging challenge of FLiRT variants: KP.1.1 and KP.2 in the global pandemic landscape, QJM: An International Journal of Medicine, Volume 117, Issue 7, July 2024, Pages 485–487, https://doi.org/10.1093/qjmed/hcae102
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Abstract
The SARS-CoV-2 virus has undergone substantial evolution, leading to emergence of new FLiRT variants characterized by specific spike mutations—F to L at position 456 and R to T at position 346—enhancing their transmissibility and immune evasion capabilities. Particularly, KP.2 shows a significant increase in cases in the USA, indicating a potential shift in the pandemic landscape due to its greater ability to evade vaccine-induced immunity and its higher effective reproduction number compared to JN.1. This evolving scenario underscores the need for continuous monitoring and adaptive response strategies to address the challenges posed by these new variants. This abstract examines the emergence of FLiRT variants KP.2 and KP1.1, descendants of the Omicron JN.1 variant, as they draw global attention amidst the ongoing coronavirus disease-2019 pandemic.
© The Author(s) 2024. Published by Oxford University Press on behalf of the Association of Physicians. All rights reserved. For permissions, please email: journals.permissions@oup.com
This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/pages/standard-publication-reuse-rights)
Topic:
- mutation
- coronavirus
- immunity
- reproductive physiological process
- vaccines
- viruses
- pandemics
- immune evasion
- sars-cov-2
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