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Seamas C Donnelly Editor-in-Chief, QJM Email: seamas.donnelly@tcd.ie Search for other works by this author on: Oxford Academic
QJM: An International Journal of Medicine, Volume 117, Issue 7, July 2024, Page 483, https://doi.org/10.1093/qjmed/hcae127
Published:
29 July 2024
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Received:
30 June 2024
Published:
29 July 2024
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Seamas C Donnelly, FLiRT a dominant COVID variant responsible for a summer surge in COVID infections, QJM: An International Journal of Medicine, Volume 117, Issue 7, July 2024, Page 483, https://doi.org/10.1093/qjmed/hcae127
See AlsoNeue Corona-Varianten namens Flirt: Symptome und Gefährlichkeit„Covid ist nie verschwunden“ – Wissenswertes über die neuen Corona-Varianten „FLiRT“The emerging challenge of FLiRT variants: KP.1.1 and KP.2 in the global pandemic landscapeNew COVID variant FLiRT may be more transmissible but unlikely to make us more sickClose
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FLiRT is a COVID variant, specifically a subvariant of JN.1. It gets its name from two specific spike mutations within its structure, namely F to L at position 456 and R to T at position 346. These mutations result in an enhanced transmissible virus with augmented immune evasion capabilities. The QJM has been at the forefront of publishing authoritative reviews on the COVID virus variants throughout the pandemic and subsequently as we learnt to live with this rapidly evolving virus.1–3 We therefore welcome the commentary piece by Dr Kumar and colleagues from the Centre for Global Health, Saveetha Medical College, India highlighting the emerging global challenges of the FLiRT variants. They review the evidence that highlights the greater ability of the FLiRT variants to evade vaccine-induced immunity and their higher effective reproduction number compared to JN.1. This evolving scenario underscores the need for continuous monitoring and adaptive response strategies to address the challenges posed by these evolving new variants.
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