Duke vs. Houston Prediction: Expert Picks, Odds, Stats and Best Bets – NCAA Tournament Final Four - Bleacher Nation (2025)

A Final Four matchup in the NCAA Tournament will see the No. 1 seed Duke Blue Devils (35-3) and the No. 1 seed Houston Cougars (34-4) square off on Saturday at 8:49 p.m. ET at Alamodome (airing on CBS) with a place in the National Championship game on the line. Duke is a 5.5-point favorite to survive and advance to the championship game. The matchup has an over/under of 136.5.

Duke vs. Houston Odds

  • Duke odds to win: -250
  • Houston odds to win: +205
  • Spread: Duke (-5.5)
  • Total: 136.5
  • Duke vs. Houston Promo Codes

    Game Time and Information

  • Date: Saturday, April 5, 2025
  • Time: 8:49 p.m. ET
  • TV: CBS
  • Where: San Antonio, Texas
  • Venue: Alamodome
  • Who Will Win Duke vs. Houston?

    Duke and Houston Betting Trends, Records Against the Spread

    Duke has a 22-11 record against the spread this season when favored by 5.5 points or more.

    These two teams average 157.7 points per game combined, 21.2 more than the total of 136.5.

    Duke and Houston have seen their opponents average a combined 15.6 fewer points per game than the over/under of 136.5 set in this matchup.

    The average total Duke has had in its matchups this season is 9.7 more points than this particular game’s point total.

    The average point total for the Cougars this season is 4.2 points fewer than this game’s over/under.

    The Blue Devils are 24-13-0 ATS this season.

    The Cougars’ ATS record is 20-17-0 this year.

    Duke Stats & Insights

    Duke averages 83.7 points per game (ninth in college basketball) while allowing 62.6 per outing (seventh in college basketball). It has a +801 scoring differential overall and outscores opponents by 21.1 points per game.

    Duke is 23rd in the nation at 35.7 rebounds per game. That’s 8.6 more than the 27.1 its opponents average.

    The Blue Devils hit 10.2 three-pointers per game (21st in college basketball), 3.3 more than their opponents (6.9). They are shooting 38.6% from beyond the arc (12th in college basketball) while allowing opponents to shoot 30.8%.

    Duke averages 111.3 points per 100 possessions on offense (first in college basketball), and allows 83.2 points per 100 possessions (sixth in college basketball).

    The Blue Devils are putting up 85.5 points per game in home games. When playing on the road, they are averaging 80.0 points per contest.

    Houston Stats & Insights

    Houston’s +599 scoring differential (outscoring opponents by 15.7 points per game) is a result of putting up 74.0 points per game (167th in college basketball) while giving up 58.3 per contest (first in college basketball).

    The 33.1 rebounds per game Houston accumulates rank 110th in the country, 6.5 more than the 26.6 its opponents collect.

    Houston makes 8.2 three-pointers per game (121st in college basketball), 1.5 more than its opponents.

    Houston ranks 40th in college basketball averaging 102.2 points per 100 possessions on offense, and defensively is second, allowing 80.5 points per 100 possessions.

    The Cougars are putting up more points at home (76.5 per game) than away (71.6).

    Duke Key Players to Watch

    The Blue Devils leader in points, rebounds and assists is Cooper Flagg, who averages 18.9 points, 7.5 boards and 4.2 assists per game.

    The Blue Devils get the most three-point shooting production out of Tyrese Proctor, who makes 2.4 threes per game.

    The Duke steals leader is Flagg, who averages 1.4 takeaways per game, while its blocks leader is Khaman Maluach, who compiles 1.3 rejections per contest.

    Houston Key Players to Watch

    LJ Cryer sits at the top of the Cougars scoring leaderboard with 15.4 points per game. Cryer also grabs 2.3 rebounds and averages 2.0 assists per game.

    The Houston leaders in rebounding and assists are J’wan Roberts with 6.3 rebounds per game (also adding 10.7 points and 1.7 assists per game) and Milos Uzan with 4.3 assists per game (also tacking on 11.6 points and 3.0 rebounds per game).

    Cryer is the top scorer from the three-point line for the Cougars, hitting 3.0 threes per game.

    Houston’s leader in steals is Emanuel Sharp with 1.4 per game, and its leader in blocks is Joseph Tugler with 1.9 per game.

    Duke vs. Houston Prediction

  • Pick ATS: Houston (+5.5)
  • Pick OU: Over (136.5)
  • Prediction:
    Duke 71, Houston 68
  • How to Bet on Duke vs. Houston

    And for more CBB game previews, NCAA basketball picks or even how to bet on college basketball check out the latest NCAAB lines on Betsperts.

    Duke vs. Houston Prediction: Expert Picks, Odds, Stats and Best Bets – NCAA Tournament Final Four - Bleacher Nation (2025)
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